My Friend's Little Sister Has It In for Me! (2025): When Annoyance Turns Into Love 🎭💫

Anime fans, mark your calendars! My Friend’s Little Sister Has It In for Me! (友達の妹が俺にだけウザい, Tomodachi no Imōto ga Ore ni Dake Uzai), also known as ImoUza, is finally making its way from page to screen. Based on Ghost Mikawa’s beloved light novel series, the highly anticipated anime adaptation will premiere on October 5, 2025 on the NUMAnimation block (TV Asahi, BS11, AT-X). With its mix of romantic comedy, heartfelt drama, and quirky characters, this series is about to become one of the most talked-about rom-com anime of the fall season.

“She’s kind and perfect at school… but why does she only act annoyingly clingy around me?” – Akiteru

🌸 The Plot: Between Games, Secrets, and Clingy Sisters

At the center of the story is Akiteru Ōboshi, a self-proclaimed average high schooler with one not-so-average problem—his best friend’s younger sister. Iroha Kohinata is bright, beautiful, and adored as the “ideal student” at school. But the moment she’s around Akiteru, her honor-student façade melts into teasing, clingy chaos.

Things get even more complicated when Akiteru’s powerful uncle proposes a deal: if Akiteru starts dating his cousin Mashiro Tsukinomori, he’ll fund their game development circle, the 5th Floor Alliance. Mashiro, however, isn’t just his cousin—she’s also a childhood friend with a frosty attitude toward him, hiding her own secrets as a successful novelist.

Meanwhile, Iroha is secretly chasing her dream of becoming a voice actress, even if it means rebelling against her family. As the 5th Floor Alliance works on creating games, the relationships between Akiteru, Iroha, Mashiro, and the rest of the eccentric cast spiral into a mix of rivalry, affection, and hidden truths.

🎤 The Characters: Voices That Bring Them to Life

The anime reunites the original drama CD cast, ensuring fans get the voices they already love:

• Akiteru Ōboshi – Voiced by Haruki Ishiya

• Iroha Kohinata – Voiced by Sayumi Suzushiro

• Mashiro Tsukinomori – Voiced by Tomori Kusunoki

• Ozuma Kohinata – Voiced by Soma Saito

• Sumire Kageishi – Voiced by Kana Hanazawa

Alongside them are more vibrant characters: the sharp-tongued teacher Sumire, her drama-club-president sister Midori, the mysterious illustrator Shikibu Murasaki, and even social media influencers who stir up school life. Each one adds layers of comedy, tension, and warmth to the story.

🎶 Music & Themes: Cute, Annoying, and Heartfelt

Anime rom-coms live and die by their theme songs, and ImoUza has delivered:

• Opening Theme: "Uza Kawaikute Nani ga Warui!" (What’s Wrong with Being Annoyingly Cute!) by Karubi Akami – a playful, upbeat anthem that captures Iroha’s energy.

• Ending Theme: "Hoshi no Kodō" (Beat of the Star) by Kohana Lam – a gentler, emotional track that highlights the story’s heart beneath the comedy.

Expect a perfect balance of lighthearted chaos and poignant emotion.

📺 Release & Streaming

• Japanese Premiere: October 5, 2025 (TV Asahi, BS11, AT-X)

• North America & Global Licensing: J-Novel Club (light novels) – anime simulcast details are expected soon, likely via Crunchyroll or HIDIVE.

Fans worldwide won’t have to wait long before Iroha’s teasing reaches every screen.

💭 Final Thoughts: Why ImoUza Will Steal the Spotlight

At first glance, My Friend’s Little Sister Has It In for Me! looks like another playful rom-com. But beneath the comedy lies a story about chasing dreams, the weight of expectations, and the surprising ways affection can grow. With its lovable cast, strong production team led by Blade Studio and director Kazuomi Koga, and music that sticks in your head, this anime is shaping up to be one of Fall 2025’s breakout hits.

As Akiteru says, “I’m just a normal guy.” But with Iroha around, nothing in his life is going to stay normal.

✨ Get ready for the laughs, the blushes, and the “annoyingly cute” moments when My Friend’s Little Sister Has It In for Me! premieres October 5, 2025.